Journal: Frontiers in Bioengineering and Biotechnology
Article Title: Novel, low-cost bioreactor for in vitro electrical stimulation of cardiac cells
doi: 10.3389/fbioe.2025.1531731
Figure Lengend Snippet: Computational modeling of electric field and fluid flow. (A) 3D electric field modeling of entire bioreactor. Cathode and anode are defined as labeled, with a 1 V applied potential used for modeling purposes. The cross-section view shown in the center is used for further 2D plots. (B) Cross section view of the electric field a single sub-well. The thin black line denotes the electric field trace 100 μm from the bottom of the well, plotted in (C) as electric field vs distance from the anode. (D) Cross-section view of current density within a single sub-well. The thin black line denotes the current density trace 100 μm from the bottom of the well, plotted in (E) as current density vs distance from the anode. (F) Computational modeling showing fluid flow streamlines originating from a rotating stir bar in the center of the device. (G) Cross section of the 3D model showing a side-view of a single sub-well. Arrows show the direction of fluid flow. (H) Shear stress at the bottom of the device, within the sub-wells, average of 5 s of modeling.
Article Snippet: 3D printed parts for the bioreactor were designed using Fusion 360 (Autodesk Inc., San Francisco) and part files are available upon request.
Techniques: Labeling, Shear